Lasers and fiber couplers as Optogenetics equipment

blue laser green laser yellow laser red laser fc coupler
 
Following lasers are widely utilized in Optogenetics (in vivo and in vitro) research as Optogenetics light sources.    
Laser power available from 10mW to several watts.

Green lasers: 532nm laser, 505nm laser, 510nm laser, 515nm laser, 520nm laser and 543nm laser 

Yellow lasers: 556nm laser, 561nm laser, 577nm laser, 589nm laser and 593.5nm laser

Red lasers: 633nm laser, 635nm laser, 637nm laser, 640nm laser, 671nm, 680nm laser and 721nm laser etc.

IR Lasers: 785nm, 808nm, 830nm, 845nm, 940nm, 980nm, 1064nm and up to 3800nm lasers etc.

UV Lasers: 257nm, 261nm, 266nm, 303nm, 320nm, 355nm, 360nm, 375nm, 380nm and 395nm lasers etc. 

 

Optogenetics stimulation laser wavelength selection guide

Opsin Type

Variant

Peak Response wavelength

Recommended lasers

Channelrhodopsins

ChR2

470nm

470nm and 473nm lasers

ChR2/T159C

C1C2

ChR2/H134R

450nm

 450nm lasers

ChETA

490nm

 488nm lasers

SFO/SSFO

470nm/ 590nm

 470nm and 589nm lasers

ReaChR

590nm

589nm and 593.5nm lasers

Chrimson/ChrimsonR

VchR1

570nm

561nm and 577nm lasers 

Chronos

500nm

501nm and 510nm lasers 

PsChR2

510nm

C1V1

540nm

 532nm and 543nm lasers

PsChR1

540nm

iChloC

465nm

 460nm and 470nm lasers

AwiChRca

475nm

 470nm and 473nm lasers

ChIEF/ChEF/ChD

460nm

 460nm lasers

Aurora

517nm

 510nm and 520nm lasers

 

Halorhodopsins

Jaws

632nm

633nm and 635nm lasers

Halo/NpHR

589nm

589nm and 593.5nm lasers 

eNpHR3.0

 

Archaerhodopsins

Arch

566nm

 561nm lasers

eArch 3.0

ArchT

eArchT 3.0

Leptosphaeria rhodopsins

Mac / eMac 3.0

540nm

 532nm and 543nm lasers

 

For Optogenetics application, following options are available: 

  • BNC connector on back of power supply offers TTL triggering and analog modulation to offer mS laser pulses.
  • Power control knob allows you to adjust laser power manually.
  • FC/PC or SMA-905 fiber coupler can couple these lasers to multimode optical fiber ( 50um,100um, 200um or 400um) with up to 90% coupling efficiency. 
Oscilloscope trace sample for TTL ( pulse width 1mS at 120Hz) modulation. 
Typical for 380nm, 405nm, 450nm, 460nm, 470nm, 520nm, 635nm, 637nm and 640nm and other semiconductor ( direct diode)  lasers.
Channel 2: TTL signal input; Channel 1: laser pulse sampled by photo diode.
diode laser
 
Oscilloscope trace sample for TTL ( pulse width 10mS at 20Hz) modulation. 
Typical for 473nm, 532nm, 556nm, 561nm, 577nm, 589nm and 593.5nm and other DPSS ( diode pumped solid state ) lasers.
Channel 2: TTL signal input; Channel 1: laser pulse sampled by photo diode.
20hz
 
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